| Lisuride | |
|---|---|
| [[File:|250px]] | |
| Formula | C₂₀H₂₆N₄O (hydrogen maleate salt) |
| Administration | Transdermal, subcutaneous, sublingual preferred; oral poorly absorbed |
| Solubility | High in water (unique among ergots) |
| Legal status | Rx in Europe; not available in US |
| Brand names | Dopergin, Cuvalit, Revanil, Proclacam |
| Bioavailability | Oral: ~10–20%; IM/SC: ~90–94% |
| Recommended dose | 0.1–0.2 mg/day (prolactin); 1.5–4.5 mg/day (Parkinson's) |
| Upper limit | ~2.4–4.8 mg/day (psychiatric effects dose-limiting) |
| LD50 | N/A, very safe at therapeutic doses |
| Ray's verdict | Recommended for high prolactin alongside ondansetron and bromocriptine as antiserotonin options. Target prolactin: 9–12. |