Pregnenolone
From WikiPeatia
| Pregnenolone | |
|---|---|
 | |
| Abbreviation | P5, PREG |
| Molecular formula | C₂₁H₃₂O₂ |
| Type | Precursor steroid hormone / neurosteroid |
| Administration | Oral (powder or capsules) or topical (in DMSO or oil). Topical administration increases half-life and effectiveness, and favors androgenic conversion pathways more than oral administration. |
| Bioavailability | When taken with food, its absorption occurs at the same rate as the digestion and absorption of the food. Oral and topical have comparable overall bioavailability. |
| Synonyms | 3β-Hydroxypregn-5-en-20-one, Δ5-Pregnenolone, P5 |
| Source | Produced in the mitochondria from cholesterol. Synthesized in the brain, adrenal glands, gonads, and skin. Brain levels of pregnenolone are about 100 times higher than in the blood, and about 30 to 550 times higher in other tissues compared to the blood. |
| Ray's verdict | Highly favorable. "When I was buying pregnenolone from the Syntex factory in Mexico, 1984–5, to test its safety I ate a kilogram of it during a year, 3000 to 4000 milligrams per day. I didn't detect any side effects at all, except that my skin, that had been sagging over my eyes and on my neck, firmed up. If pregnenolone is pure, it's effective in doses as small as 10 mg. Ray recommends 100-150mg for stress inhibition. I've only seen a couple of people younger than their late 40s who felt anything at all from it. And a single dose is often all it takes, and continued, or bigger, doses don't do anything more. Key caveat: Pregnenolone has its own effects distinct from DHEA's; I think it's important to find a well refined pregnenolone." |
Introduction[edit]
"I have seen grey-skinned depressed people turn pink and start smiling shortly after taking pregnenolone." - Ray Peat
